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B12

Those on an animal free diet will not obtain B12 directly from animal foods. However 1. Many people may consume an adequate amount but not be able to absorb it. 2. Eating lots of organic veggies without thoroughly washing them to clinical standards means you may get some anyway. B12 is the excretion of a bacteria. :)  3. And how do fruitarians cope? :lalala:

cyano or methyl b12

Cyanide and Vit B12 (OT)

"When most of us think of vitamin B12, the molecule we really have in mind is cyanocobalamin or cyano B12. As its name suggests, cyano B12 has a cyanide group (CN) attached, whereas methyl B12 carries a methyl group (CH3) instead. Very little of the body''s natural B12 is in the cyano form under normal circumstances; ....."
www.drugs.com

B12 Definition: generic descriptor for compounds exhibiting the biologic activity of cyanocobalamin; the antianemia factor of liver extract that contains cobalt, a cyano group, and corrin in a cobamide structure. Several substances with similar formulas and with the characteristic hematinic action have been isolated and designated: B12a, hydroxocobalamin; B12b, aquacobalamin; B12c, nitritocobalamin; B12r, cob(II)alamin; B12s, cob(I)alamin; B12III, factors A and V1a (cobyric acid) and pseudovitamin B12.


Info added on 11th October 2013

Vitamin B12 Digestion and Absorption

Dietary vitamin B12 is linked to proteins found in food. The link must be cleaved by hydrochloric acid and a gastric enzyme called pepsin once the food enters the stomach. Vitamin B12 that is found in supplements or fortified food does not require this step. In the stomach, the cobalamins are bound to a non-enzymatic protein called R protein. The bound vitamin travels to the small intestine. At this time, a glycoprotein called intrinsic factor, or IF, is secreted by the gastric parietal cells. Both the R protein-B12 complex and IF enter the small intestine, where enzymes break down the R protein and leave B12 free to bind with IF. The cobalamin-IF complex then travels to the ileum, the furthest part of the small intestine, where it is absorbed. B12 can be absorbed anywhere along the ileal surface, but absorption occurs mainly in the last third.

Risk for Deficiency

Given that stomach acid and intrinsic factor are both needed for the successful digestion and absorption of vitamin B12, the elderly--since stomach acid secretion naturally declines with age--in addition to individuals with pernicious anaemia, an autoimmune disorder that results in the decline of gastric tissue and parietal cells and thus intrinsic factor, can be at risk for deficiency. Individuals with pancreatic insufficiency can also be at risk for deficiency, given the reduction of pancreatic enzymatic action on the cleavage of the R-protein-B12 complex, leaving the B12 unavailable to bind with IF and be absorbed. In addition, anyone who has a gastrointestinal disorder, such as Crohns, or has had a surgery that either removes or bypasses the stomach or distal ileum is at risk for deficiency. The absorption of vitamin B12 found naturally in food requires an intact and functioning stomach, exocrine pancreas, intrinsic factor and small bowel.

Read more: how-is-vitamin-b12-absorbed-by-the-body

', '2014-01-19 16:26:14'),

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This entry was posted by elf and filed under Nutrients.
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1 comment

Comment from: roger Member

The literature data on the acute toxicity profile of hydroxocobalamin show it is generally regarded as safe with local and systemic exposure. The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure.[18][19] The US FDA at the end of 2006 approved the use hydroxocobalamin as an injection for the treatment of cyanide poisoning.
https://en.wikipedia.org/wiki/Hydroxocobalamin#Cyanide_poisoning

13/07/17 @ 09:31

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